Dynamically Accumulating Homologous Recombination Deficiency Score Served as an Important Prognosis Factor in High-Grade Serous Ovarian Cancer

Dynamically Accumulating Homologous Recombination Deficiency Score Served as an Important Prognosis Factor in High-Grade Serous Ovarian Cancer

Background: The homologous recombination (HR) pathway defects in cancers induced abrogation of cell cycle checkpoints, resulting in the accumulation of DNA damage, mitotic catastrophe, and cell death. Cancers with BRCA1/2 loss and other accumulation of similar genomic scars resulting in HRD displaye...

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Bibliographic Details
Main Authors: Rongjia Su, Yuan Liu, Xiaomei Wu, Jiangdong Xiang, Xiaowei Xi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
BRCA
homologous recombination deficiency
ovarian cancer
PARP inhibitors
WGCNA
overall survival
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.762741/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.762741/full

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