Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage

Fused in sarcoma (FUS) is a RNA/DNA protein involved in multiple nuclear and cytoplasmic functions including transcription, splicing, mRNA trafficking, and stress granule formation. To accomplish these many functions, FUS must shuttle between cellular compartments in a highly regulated manner. When...

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Bibliographic Details
Main Authors: Michelle A. Johnson, Qiudong Deng, Georgia Taylor, Zachary T. McEachin, Anthony W.S. Chan, Jessica Root, Gary J. Bassell, Thomas Kukar
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Neurobiology of Disease
Subjects:
Frontotemporal dementia (FTD)
Amyotrophic lateral sclerosis (ALS)
Fused in sarcoma (FUS)
DNA-dependent protein kinase (DNA-PK)
DNA damage
Phosphorylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120303600

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http://www.sciencedirect.com/science/article/pii/S0969996120303600

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