Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal–Glial Synapses and Reduced Expression in <i>Nlgn3<sup>R451C</sup></i> Mice

Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal–Glial Synapses and Reduced Expression in <i>Nlgn3<sup>R451C</sup></i> Mice

Mutations in the Neuroligin-3 (<i>Nlgn3</i>) gene are implicated in autism spectrum disorder (ASD) and gastrointestinal (GI) dysfunction, but cellular <i>Nlgn3</i> expression in the enteric nervous system remains to be characterised. We combined RNAScope in situ hybridization...

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Bibliographic Details
Main Authors: Madushani Herath, Ellie Cho, Ulrika Marklund, Ashley E. Franks, Joel C. Bornstein, Elisa L. Hill-Yardin
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomolecules
Subjects:
neuroligin-3
autism
enteric nervous system
glia
ileum
RNAScope
Online Access:https://www.mdpi.com/2218-273X/13/7/1063

Internet

https://www.mdpi.com/2218-273X/13/7/1063

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