Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis

Abstract Background Sepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration, agitation, or coma and is associated with poor outcome in the early phase of sepsis. In addition, sepsis survivors often suffer from persisting memory...

Full description

Bibliographic Details
Main Authors: Nils Mein, Nikolai von Stackelberg, Jonathan Wickel, Christian Geis, Ha-Yeun Chung
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:https://doi.org/10.1186/s12974-023-02975-8