Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines

Genetic analysis and molecular basis of G6PD deficiency among malaria patients in Thailand: implications for safe use of 8-aminoquinolines

Abstract Background It was hypothesized that glucose-6-phosphate dehydrogenase (G6PD) deficiency confers a protective effect against malaria infection, however, safety concerns have been raised regarding haemolytic toxicity caused by radical cure with 8-aminoquinolines in G6PD-deficient individuals....

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Bibliographic Details
Main Authors: Usa Boonyuen, Beatriz Aira C. Jacob, Jutamas Wongwigkan, Kamonwan Chamchoy, Natsamon Singha-art, Natnicha Pengsuk, Duantida Songdej, Emily R. Adams, Thomas Edwards, Supat Chamnanchanunt, Syazwani Itri Amran, Nurriza Ab Latif, Naveen Eugene Louis, Shamini Chandran
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Malaria Journal
Subjects:
G6PD deficiency
Malaria
G6PD mutations
G6PD genotyping
Synonymous mutations
Stability
Online Access:https://doi.org/10.1186/s12936-024-04864-8

Internet

https://doi.org/10.1186/s12936-024-04864-8

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