Long non-coding RNA rhabdomyosarcoma 2-associated transcript contributes to neuropathic pain by recruiting HuR to stabilize DNA methyltransferase 3 alpha mRNA expression in dorsal root ganglion neuron

Long non-coding RNA rhabdomyosarcoma 2-associated transcript contributes to neuropathic pain by recruiting HuR to stabilize DNA methyltransferase 3 alpha mRNA expression in dorsal root ganglion neuron

IntroductionLong non-coding RNAs (lncRNAs) act as key regulators in multiple human diseases. In particular, the dysfunction of lncRNAs in dorsal root ganglion (DRG) contributes to the pathogenesis of neuropathic pain (NP). Nevertheless, the role and mechanism of most lncRNAs in NP remain unclear.Met...

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Bibliographic Details
Main Authors: Xinying Guo, Gaolong Zhang, Weihua Cai, Fa Huang, Jingwen Qin, Xingrong Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuropathic pain
dorsal root ganglia
Rmst lncRNA
HuR
DNA methyltransferase 3 alpha (DNMT3A)
mRNA stability
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.1027063/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.1027063/full

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