Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy

Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy

Multiple myeloma (MM) is an incurable hematological malignancy that lacks effective therapeutic interventions. Ferroptosis is a newly discovered form of cell death that has shown great potential for MM therapy. As a proteasome inhibitor and necroptosis inducer, shikonin (SHK) performs dual functions...

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Bibliographic Details
Main Authors: Wenxia Li, Hangjie Fu, Liuyuan Fang, Hui Chai, Tianwen Gao, Zhenzhen Chen, Shenxian Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
shikonin
ferroptosis
ferritinophagy
GOT1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1025067/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1025067/full

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