Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Biparatopic nanobodies targeting the receptor binding domain efficiently neutralize SARS-CoV-2

Summary: The development of therapeutics to prevent or treat COVID-19 remains an area of intense focus. Protein biologics, including monoclonal antibodies and nanobodies that neutralize virus, have potential for the treatment of active disease. Here, we have used yeast display of a synthetic nanobod...

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Bibliographic Details
Main Authors: Phillip Pymm, Samuel J. Redmond, Olan Dolezal, Francesca Mordant, Ester Lopez, James P. Cooney, Kathryn C. Davidson, Ebene R. Haycroft, Chee Wah Tan, Rebecca Seneviratna, Samantha L. Grimley, Damian F.J. Purcell, Stephen J. Kent, Adam K. Wheatley, Lin-Fa Wang, Andrew Leis, Alisa Glukhova, Marc Pellegrini, Amy W. Chung, Kanta Subbarao, Adam P. Uldrich, Wai-Hong Tham, Dale I. Godfrey, Nicholas A. Gherardin
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Immunology
microbiology
structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015310

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222015310

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