Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents

Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents

Through a two-step procedure, 3-amino-7-chloro-2-methylquinazolin-4(3H)-one was synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with chloro acetylchloride, then nucleophilically substituted with various secondary amines to produce acetamide derivatives (5a-e)...

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Bibliographic Details
Main Authors: Sherin M. Elfeky, Samar J. Almehmadi, Samar S. Tawfik
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Arabian Journal of Chemistry
Subjects:
7-chloro-2-methylquinazolin-4(3H)-ones
PI3k-δ enzyme
Cytotoxic Activity
Molecular docking
Enzyme inhibition
ADME studies
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221006298

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http://www.sciencedirect.com/science/article/pii/S1878535221006298

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