Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum

Chronic neuroinflammation during aging leads to cholinergic neurodegeneration in the mouse medial septum

Abstract Background Low-grade, chronic inflammation in the central nervous system characterized by glial reactivity is one of the major hallmarks for aging-related neurodegenerative diseases like Alzheimer’s disease (AD). The basal forebrain cholinergic neurons (BFCN) provide the primary source of c...

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Bibliographic Details
Main Authors: Rashmi Gamage, Ilaria Rossetti, Garry Niedermayer, Gerald Münch, Yossi Buskila, Erika Gyengesi
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Healthy aging
Microglia
Cholinergic system
Animal-mouse
Stereology
Online Access:https://doi.org/10.1186/s12974-023-02897-5

Internet

https://doi.org/10.1186/s12974-023-02897-5

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