How good are AlphaFold models for docking-based virtual screening?

Summary: A crucial component in structure-based drug discovery is the availability of high-quality three-dimensional structures of the protein target. Whenever experimental structures were not available, homology modeling has been, so far, the method of choice. Recently, AlphaFold (AF), an artificia...

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Bibliographic Details
Main Authors: Valeria Scardino, Juan I. Di Filippo, Claudio N. Cavasotto
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222021939