The Effect of Disulfiram and N-Acetylcysteine, Potential Compensators for Sulfur Disorders, on Lipopolysaccharide-Induced Neuroinflammation Leading to Memory Impairment and the Metabolism of L-Cysteine Disturbance

The Effect of Disulfiram and N-Acetylcysteine, Potential Compensators for Sulfur Disorders, on Lipopolysaccharide-Induced Neuroinflammation Leading to Memory Impairment and the Metabolism of L-Cysteine Disturbance

Background: The role of sulfur-containing drugs, disulfiram (DSF) and N-acetylcysteine (NAC), in alleviating neuroinflammation is poorly understood. The objective of this study was to examine the effect of DSF and NAC on memory and on the metabolism of L-cysteine and inflammation-related parameters...

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Bibliographic Details
Main Authors: Małgorzata Iciek, Anna Bilska-Wilkosz, Magdalena Górny, Marek Bednarski, Małgorzata Zygmunt, Anthea Miller, Noemi Nicosia, Giorgia Pia Lombardo, Paula Zammit, Magdalena Kotańska
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Molecules
Subjects:
disulfiram
hydrogen sulfide
lipopolysaccharide
N-acetylcysteine
neuroinflammation
non-protein thiols
Online Access:https://www.mdpi.com/1420-3049/30/3/578

Internet

https://www.mdpi.com/1420-3049/30/3/578

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