Short PDE4 Isoforms as Drug Targets in Disease

Short PDE4 Isoforms as Drug Targets in Disease

The second messenger, cyclic adenosine monophosphate (cAMP), is a master regulator of signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis by adenylyl cyclase and degradation by phosphodiesterases (PDEs) underpins receptor-specific responses. As multiple recepto...

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Bibliographic Details
Main Authors: Elka Kyurkchieva, George S. Baillie
Format: Article
Language:English
Published: IMR Press 2023-07-01
Series:Frontiers in Bioscience-Landmark
Subjects:
phosphodiesterase
cyclic amp
short isoform
inflammation
multiple sclerosis
alzheimer's disease
traumatic brain injury
cancer
chronic obstructive pulmonary disease
drug target
Online Access:https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807133

Internet

https://www.imrpress.com/journal/FBL/28/7/10.31083/j.fbl2807133

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