A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows

A high-concentrate diet induces inflammatory injury via regulating Ca2+/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows

IntroductionCalmodulin-dependent protein kinase β (CaMKKβ) is closely related to Ca2+ concentration. An increase in Ca2+ concentration in the cytoplasm activates CaMKKβ, and activated CaMKKβ affects the activities of AMPK and mTOR and induces autophagy. A high-concentrate diet leads to Ca2+ disorder...

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Bibliographic Details
Main Authors: Meijuan Meng, Xuerui Li, Zihan Wang, Ran Huo, Nana Ma, Guangjun Chang, Xiangzhen Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
subacute rumen acidosis
mammary gland tissue
CaMKKβ
autophagy
inflammation
LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186170/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1186170/full

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