Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae

Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae

Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology. Optic atrophy and hearing impairment are the most prevalent clinical features associated with mutations in the OPA1 gene, but the function of OP...

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Bibliographic Details
Main Authors: Tingting Dong, Xuejie Zhang, Yiqing Liu, Shan Xu, Haishuang Chang, Fengqiu Chen, Lulu Pan, Shaoru Hu, Min Wang, Min Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
OPA1
mitochondria
cisplatin
apoptosis
ototoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.744838/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.744838/full

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