Effects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media

Effects of Different Weak Small Organic Acids on Clofazimine Solubility in Aqueous Media

Background/Objectives: Clofazimine (CFZ) is a Biopharmaceutics Classification System (BCS) II drug introduced in the US market in 1986 for the treatment of leprosy. However, CFZ was later withdrawn from the market due to its extremely low aqueous solubility and low absorption. In the literature, the...

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Bibliographic Details
Main Authors: Igor A. Topalović, Olivera S. Marković, Miloš P. Pešić, Mufaddal H. Kathawala, Martin Kuentz, Alex Avdeef, Abu T. M. Serajuddin, Tatjana Ž. Verbić
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
clofazimine
acid–base supersolubilization (ABS)
solubility
glutaric acid
tartaric acid
malic acid
Online Access:https://www.mdpi.com/1999-4923/16/12/1545

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https://www.mdpi.com/1999-4923/16/12/1545

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