Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies

Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies

BackgroundChordoma is a rare, invasive, and devastating bone malignancy of residual notochord tissue that arises at the skull base, sacrum, or spine. In order to maximize immunotherapeutic approaches as a potential treatment strategy in chordoma it is important to fully characterize the tumor immune...

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Bibliographic Details
Main Authors: Diana C. Lopez, Yvette L. Robbins, Joshua T. Kowalczyk, Wiem Lassoued, James L. Gulley, Markku M. Miettinen, Gary L. Gallia, Clint T. Allen, James W. Hodge, Nyall R. London
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
chordoma
tumor immune microenvironment (TIME)
immunotherapy
myeloid cells
T cells
natural killer cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1012058/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1012058/full

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