Regulators of proteostasis are translationally repressed in fibroblasts from patients with sporadic and LRRK2-G2019S Parkinson’s disease

Abstract Deficits in protein synthesis are associated with Parkinson’s disease (PD). However, it is not known which proteins are affected or if there are synthesis differences between patients with sporadic and Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S PD, the most common monogenic form. Here we u...

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Bibliographic Details
Main Authors: Dani Flinkman, Ye Hong, Jelena Gnjatovic, Prasannakumar Deshpande, Zsuzsanna Ortutay, Sirkku Peltonen, Valtteri Kaasinen, Peter James, Eleanor Coffey
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-023-00460-w