In-situ biophysical characterization of high-concentration protein formulations using wNMR

In-situ biophysical characterization of high-concentration protein formulations using wNMR

ABSTRACTHigh-concentration protein formulation is of paramount importance in patient-centric drug product development, but it also presents challenges due to the potential for enhanced aggregation and increased viscosity. The analysis of critical quality attributes often necessitates the transfer of...

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Bibliographic Details
Main Authors: Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Accelerated stress
biologics
drug product stability
high-concentration drug product
mABs
protein aggregation
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2304624

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2024.2304624

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