Mature Myotubes Generated From Human-Induced Pluripotent Stem Cells Without Forced Gene Expression

Mature Myotubes Generated From Human-Induced Pluripotent Stem Cells Without Forced Gene Expression

Human-induced pluripotent stem cells (hiPSCs) are a promising tool for disease modeling and drug screening. To apply them to skeletal muscle disorders, it is necessary to establish mature myotubes because the onset of many skeletal muscle disorders is after birth. However, to make mature myotubes, t...

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Bibliographic Details
Main Authors: Kei Fujiwara, Risa Yamamoto, Tomoya Kubota, Atsutoshi Tazumi, Tomoka Sabuta, Masanori P. Takahashi, Hidetoshi Sakurai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myogenic differentiation
mature myotube
human iPS cell
transgene free
screening tools
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.886879/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.886879/full

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