SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans

SERCA inhibition improves lifespan and healthspan in a chemical model of Parkinson disease in Caenorhabditis elegans

Introduction: The high prevalence of neurodegenerative diseases in our population and the lack of effective treatments encourage the search for new therapeutic targets for these pathologies. We have recently described that submaximal inhibition of the Sarco-Endoplasmic Reticulum Ca2+ ATPase (SERCA),...

Full description

Bibliographic Details
Main Authors: Silvia Romero-Sanz, Elena Caldero-Escudero, Pilar Álvarez-Illera, Jaime Santo-Domingo, Rosalba I. Fonteriz, Mayte Montero, Javier Álvarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
C. elegans
rotenone
Parkinson’s disease
SERCA
lifespan
endoplasmic reticulum
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1182428/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1182428/full

Similar Items