The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.

The ratios of CD8+ T cells to CD4+CD25+ FOXP3+ and FOXP3- T cells correlate with poor clinical outcome in human serous ovarian cancer.

Ovarian cancer is an immune reactive malignancy with a complex immune suppressive network that blunts successful immune eradication. This suppressive microenvironment may be mediated by recruitment or induction of CD4(+) regulatory T cells (Tregs). Our study sought to investigate the association of...

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Bibliographic Details
Main Authors: Claudia C Preston, Matthew J Maurer, Ann L Oberg, Daniel W Visscher, Kimberly R Kalli, Lynn C Hartmann, Ellen L Goode, Keith L Knutson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3828213?pdf=render

Internet

http://europepmc.org/articles/PMC3828213?pdf=render

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