Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity

Glutaraldehyde-crosslinked chitosan-polyethylene oxide nanofibers as a potential gastroretentive delivery system of nizatidine for augmented gastroprotective activity

Nizatidine (NIZ), a histamine H2-receptor antagonist, is soluble and stable in the stomach, however, it exhibits a short half-life and a rapid clearance. Therefore, chitosan (CS) and polyethylene oxide (PEO) nanofibers (NFs) at different weight ratios were prepared by electrospinning and characteriz...

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Bibliographic Details
Main Authors: Walaa Ebrahim Abd El Hady, Osama Abd El-Aazeem Soliman, Hassan Mohamed El Sabbagh, Elham Abdelmonem Mohamed
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
nizatidine
chitosan
nanofibers
gastroretention
gastroprotective activity
Online Access:http://dx.doi.org/10.1080/10717544.2021.1971796

Internet

http://dx.doi.org/10.1080/10717544.2021.1971796

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