Determining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance

Determining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance

ABSTRACTAccurate and efficient affinity measurement techniques are essential for the biophysical characterization of therapeutic monoclonal antibodies, one of the fastest growing drug classes. Surface plasmon resonance (SPR) is widely used for determining antibody affinity, but does not perform well...

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Bibliographic Details
Main Authors: M. Frank Erasmus, Molly Dovner, Fortunato Ferrara, Sara D’Angelo, André A. Teixeira, Camila Leal-Lopes, Laura Spector, Elizabeth Hopkins, Andrew R. M. Bradbury
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Antibody
drug discovery
antibody therapeutics
surface plasmon resonance
kinetic exclusion assay
antibody characterization
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2291209

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2291209

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