A Stepwise Algorithm for Linearly Combining Biomarkers under Youden Index Maximization

A Stepwise Algorithm for Linearly Combining Biomarkers under Youden Index Maximization

Combining multiple biomarkers to provide predictive models with a greater discriminatory ability is a discipline that has received attention in recent years. Choosing the probability threshold that corresponds to the highest combined marker accuracy is key in disease diagnosis. The Youden index is a...

Full description

Bibliographic Details
Main Authors: Rocío Aznar-Gimeno, Luis M. Esteban, Rafael del-Hoyo-Alonso, Ángel Borque-Fernando, Gerardo Sanz
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Mathematics
Subjects:
linear combination
stepwise algorithm
Youden index
biomarkers
diagnosis
Online Access:https://www.mdpi.com/2227-7390/10/8/1221

Similar Items

Similar Items