The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion, through interaction with YBX1 and induction of I...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22746-4 |
| _version_ | 1830083050906583040 |
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| author | Marta Montes Michal Lubas Frederic S. Arendrup Bettina Mentz Neha Rohatgi Sarunas Tumas Lea M. Harder Anders J. Skanderup Jens S. Andersen Anders H. Lund |
| author_facet | Marta Montes Michal Lubas Frederic S. Arendrup Bettina Mentz Neha Rohatgi Sarunas Tumas Lea M. Harder Anders J. Skanderup Jens S. Andersen Anders H. Lund |
| author_sort | Marta Montes |
| collection | DOAJ |
| description | Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion, through interaction with YBX1 and induction of IL1A translation. |
| first_indexed | 2024-12-14T16:13:05Z |
| format | Article |
| id | doaj.art-8da6f54bfa9d4666b2534cafaba5a56a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T16:13:05Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8da6f54bfa9d4666b2534cafaba5a56a2022-12-21T22:54:57ZengNature PortfolioNature Communications2041-17232021-04-0112111710.1038/s41467-021-22746-4The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotypeMarta Montes0Michal Lubas1Frederic S. Arendrup2Bettina Mentz3Neha Rohatgi4Sarunas Tumas5Lea M. Harder6Anders J. Skanderup7Jens S. Andersen8Anders H. Lund9Biotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenBiotech Research and Innovation Centre, University of CopenhagenGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)Biotech Research and Innovation Centre, University of CopenhagenDepartment of Biochemistry and Molecular Biology, University of Southern DenmarkGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)Department of Biochemistry and Molecular Biology, University of Southern DenmarkBiotech Research and Innovation Centre, University of CopenhagenSenescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion, through interaction with YBX1 and induction of IL1A translation.https://doi.org/10.1038/s41467-021-22746-4 |
| spellingShingle | Marta Montes Michal Lubas Frederic S. Arendrup Bettina Mentz Neha Rohatgi Sarunas Tumas Lea M. Harder Anders J. Skanderup Jens S. Andersen Anders H. Lund The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype Nature Communications |
| title | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
| title_full | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
| title_fullStr | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
| title_full_unstemmed | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
| title_short | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
| title_sort | long non coding rna mir31hg regulates the senescence associated secretory phenotype |
| url | https://doi.org/10.1038/s41467-021-22746-4 |
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