Binding Parameters of [<sup>11</sup>C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents

Binding Parameters of [<sup>11</sup>C]MPC-6827, a Microtubule-Imaging PET Radiopharmaceutical in Rodents

Impairment and/or destabilization of neuronal microtubules (MTs) resulting from hyper-phosphorylation of the tau proteins is implicated in many pathologies, including Alzheimer’s disease (AD), Parkinson’s disease and other neurological disorders. Increasing scientific evidence indicates that MT-stab...

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Bibliographic Details
Main Authors: Avinash H. Bansode, Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Ivan Krizan, Mack Miller, Suzanne Craft, Akiva Mintz, Kiran Kumar Solingapuram Sai
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceuticals
Subjects:
PET imaging
microtubules
radiochemistry
metabolism
stability
translational molecular imaging
Online Access:https://www.mdpi.com/1424-8247/16/4/495

Internet

https://www.mdpi.com/1424-8247/16/4/495

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