Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide

Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide

Calcific aortic valve disease (CAVD) is an increasingly prevalent condition among the elderly population that is associated with significant morbidity and mortality. Insufficient understanding of the underlying disease mechanisms has hindered the development of pharmacologic therapies for CAVD. Rece...

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Bibliographic Details
Main Authors: Uddalak Majumdar, Talita Z. Choudhury, Sathiyanarayanan Manivannan, Yukie Ueyama, Madhumita Basu, Vidu Garg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
calcific aortic valve disease
nitric oxide
S-nitrosylation
single cell RNA-sequencing
integrin signaling
extracellular matrix (ECM)
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.742850/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.742850/full

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