Neutralizing Activity of Anti-interferon-γ Autoantibodies in Adult-Onset Immunodeficiency Is Associated With Their Binding Domains

Neutralizing Activity of Anti-interferon-γ Autoantibodies in Adult-Onset Immunodeficiency Is Associated With Their Binding Domains

Adult-onset immunodeficiency (AOID) with anti-interferon-γ (IFN-γ) autoantibodies (autoAbs) is an emerging immunodeficiency syndrome in Asian countries. The presence of neutralizing anti-IFN-γ autoAbs are significantly associated with severe disseminated opportunistic infections. However, the charac...

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Bibliographic Details
Main Authors: Umpa Yasamut, Weeraya Thongkum, Sutpirat Moonmuang, Supachai Sakkhachornphop, Romanee Chaiwarith, Jutarat Praparattanapan, Jiraprapa Wipasa, Kriangkrai Chawansuntati, Khuanchai Supparatpinyo, Ethan Lai, Chatchai Tayapiwatana
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
interferon-γ
anti-interferon-γ autoantibody
neutralizing antibody
competitive-binding ELISA
adult-onset immunodeficiency
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01905/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01905/full

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