Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

Drug metabolism by the microbiome can influence anticancer treatment success. We previously suggested that chemotherapies with antimicrobial activity can select for adaptations in bacterial drug metabolism that can inadvertently influence the host’s chemoresistance. We demonstrated that evolved resi...

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Bibliographic Details
Main Authors: Serkan Sayin, Brittany Rosener, Carmen G Li, Bao Ho, Olga Ponomarova, Doyle V Ward, Albertha JM Walhout, Amir Mitchell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
gemcitabine
microbiome
chemoresistance
cancer
drug adaptation
resistome
Online Access:https://elifesciences.org/articles/83140

Internet

https://elifesciences.org/articles/83140

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