Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade

Different Expression Characteristics of LAG3 and PD-1 in Sepsis and Their Synergistic Effect on T Cell Exhaustion: A New Strategy for Immune Checkpoint Blockade

The impairment of immunity characterized by T cell exhaustion is the main cause of death in patients with sepsis after the acute phase. Although PD-1 blockade is highly touted as a promising treatment for improving prognosis, the role of PD-1 plays in sepsis and particularly its different roles in d...

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Bibliographic Details
Main Authors: Bailin Niu, Fachun Zhou, Yanxin Su, Long Wang, Yuanyuan Xu, Ziying Yi, Yushen Wu, Huimin Du, Guosheng Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
T cell exhaustion
sepsis
PD-1
LAG3
synergistic inhibition
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01888/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01888/full

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