Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits

Abstract Background Identification of genetic risk factors that are shared between Alzheimer’s disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Previous epidemiological correlations observed betw...

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Bibliographic Details
Main Authors: William P. Bone, Katherine M. Siewert, Anupama Jha, Derek Klarin, Scott M. Damrauer, The VA Million Veteran Program, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes, Marylyn D. Ritchie, Benjamin F. Voight
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Alzheimer’s Research & Therapy
Subjects:
Pleiotropy
Cardiometabolic traits
Multi-trait GWAS
Colocalization
Online Access:https://doi.org/10.1186/s13195-021-00773-z

Internet

https://doi.org/10.1186/s13195-021-00773-z

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