Histidine 19 Residue Is Essential for Cell Internalization of Antifungal Peptide SmAP<sub>α1-21</sub> Derived from the α-Core of the <i>Silybum marianum</i> Defensin DefSm2-D in <i>Fusarium graminearum</i>

Histidine 19 Residue Is Essential for Cell Internalization of Antifungal Peptide SmAP<sub>α1-21</sub> Derived from the α-Core of the <i>Silybum marianum</i> Defensin DefSm2-D in <i>Fusarium graminearum</i>

The synthetic peptide SmAP<sub>α1-21</sub> (KLCEKPSKTWFGNCGNPRHCG) derived from DefSm2-D defensin α-core is active at micromolar concentrations against the phytopathogenic fungus <i>Fusarium graminearum</i> and has a multistep mechanism of action that includes alteration of t...

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Bibliographic Details
Main Authors: Agustina Fernández, Mariano González, Ismael Malbrán, Romina F. Vázquez, Sabina M. Maté, Fanny Guzmán, Laura S. Bakás, Sandra Vairo Cavalli
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Antibiotics
Subjects:
defensins
antimicrobial peptides
antifungal peptides
<i>Fusarium graminearum</i>
antifungal peptide design
Fusarium head blight
Online Access:https://www.mdpi.com/2079-6382/11/11/1501

Internet

https://www.mdpi.com/2079-6382/11/11/1501

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