An interpretable machine learning pipeline based on transcriptomics predicts phenotypes of lupus patients

Summary: Machine learning (ML) has the potential to identify subsets of patients with distinct phenotypes from gene expression data. However, phenotype prediction using ML has often relied on identifying important genes without a systems biology context. To address this, we created an interpretable...

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Bibliographic Details
Main Authors: Emily L. Leventhal, Andrea R. Daamen, Amrie C. Grammer, Peter E. Lipsky
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223021193