Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis

Heat shock protein A4 ablation leads to skeletal muscle myopathy associated with dysregulated autophagy and induced apoptosis

Abstract Background Molecular chaperones assist protein folding, facilitate degradation of misfolded polypeptides, and thereby maintain protein homeostasis. Impaired chaperone activity leads to defective protein quality control that is implicated in multiple skeletal muscle diseases. The heat shock...

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Bibliographic Details
Main Authors: Manar Elkenani, Amal Z. Barakat, Torsten Held, Daniel Marques Rodrigues, Sherok Mobarak, Surabhi Swarnka, Ibrahim M. Adham, Belal A. Mohamed
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
HSPs
Myopathy
Autophagy
Online Access:https://doi.org/10.1186/s12967-022-03418-3

Internet

https://doi.org/10.1186/s12967-022-03418-3

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