Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages

Transcriptomic analysis reveals that RasGEF1b deletion alters basal and LPS-induced expression of genes involved in chemotaxis and cytokine responses in macrophages

Abstract Ras guanine nucleotide exchange factor member 1b (RasGEF1b) of the RasGEF/CDC25 domain-containing family is preferentially expressed by macrophages. However, information is lacking about its role in macrophage function. In this study, we generated mice with ubiquitous deletion of Rasgef1b a...

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Bibliographic Details
Main Authors: Heliana B. Fernandes, Isadora Mafra de Oliveira, Thomas S. Postler, Sérgio Q. Lima, Cícera A. C. Santos, Michaelle S. Oliveira, Felipe B. Leão, Sankar Ghosh, Maria C. Souza, Warrison Andrade, Aristóbolo M. Silva
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47040-9

Internet

https://doi.org/10.1038/s41598-023-47040-9

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