The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-β as a Companion Target for Checkpoint Blockade Immunotherapy

The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-β as a Companion Target for Checkpoint Blockade Immunotherapy

Extrinsic factors such as expression of PD-L1 (programmed dealth-ligand 1) in the tumor microenvironment (TME) have been shown to correlate with responses to checkpoint blockade therapy. More recently two intrinsic factors related to tumor genetics, microsatellite instability (MSI), and tumor mutati...

Full description

Bibliographic Details
Main Authors: Bjarne Bartlett, Zitong Gao, Monique Schukking, Mark Menor, Vedbar S. Khadka, Muller Fabbri, Peiwen Fei, Youping Deng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PD-L1
immunotherapy
checkpoint blockade
MSI
mutation burden
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.754507/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.754507/full

Similar Items