Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling

Early enterovirus translation deficits extend viral RNA replication and elicit sustained MDA5-directed innate signaling

ABSTRACTEnteroviruses (EVs)—positive-sense single-strand RNA viruses of Picornaviridae—are among the most common human viral pathogens. Unlike other cytoplasmic viral RNAs (vRNAs), which are detected by RIG-I, sensing of EV RNAs is mediated primarily by MDA5. EVs evolved with rapid, cytotoxic life c...

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Bibliographic Details
Main Authors: Mikhail I. Dobrikov, Elena Y. Dobrikova, Dasean T. Nardone-White, Zachary P. McKay, Michael C. Brown, Matthias Gromeier
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
poliovirus
MDA5
interferon
IRF3
eIF4G
Online Access:https://journals.asm.org/doi/10.1128/mbio.01915-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01915-23

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