EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy

EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy

Abstract Graves’ ophthalmopathy (GO) is an extra-thyroidal complication of Graves’ disease which can lead to vision loss in severe cases. Currently, treatments of GO are not sufficiently effective, so novel therapeutic strategies are needed. As platelet-derived growth factor (PDGF)-BB induces severa...

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Bibliographic Details
Main Authors: Sopita Visamol, Tanapat Palaga, Preamjit Saonanon, Vannakorn Pruksakorn, Nattiya Hirankarn, P. Martin van Hagen, Willem A. Dik, Sita Virakul
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Histone lysine methyltransferases
EZH2
H3K27me3
Graves’ ophthalmopathy
Orbital fibroblast
Online Access:https://doi.org/10.1038/s41598-024-57926-x

Internet

https://doi.org/10.1038/s41598-024-57926-x

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