Impact of Hydrophobic, Hydrophilic, and Mucus-Binding Motifs on the Therapeutic Potential of Ceftazidime Analogs for Pulmonary Administration

Impact of Hydrophobic, Hydrophilic, and Mucus-Binding Motifs on the Therapeutic Potential of Ceftazidime Analogs for Pulmonary Administration

<b>Background/Objectives</b>: The pulmonary administration of antibiotics can be advantageous in treating pulmonary infections by promoting high intrapulmonary drug concentrations with reduced systemic exposure. However, limited benefits have been observed for pulmonary administration ve...

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Detalles Bibliográficos
Autores principales: Kyle D. Apley, Stephanie N. Johnson, Jian Qian, Indeewara Munasinghe, Jennifer R. Klaus, Srilaxmi M. Patel, Kathryn E. Woods, Samalee Banerjee, Josephine R. Chandler, Chamani Perera, Nathalie Baumlin, Matthias Salathe, Cory J. Berkland
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2025-02-01
Colección:Antibiotics
Materias:
antibacterial(s)
drug design
drug transport
epithelial permeability
pulmonary drug delivery
Acceso en línea:https://www.mdpi.com/2079-6382/14/2/177

Internet

https://www.mdpi.com/2079-6382/14/2/177

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