GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway

Abstract The effect of glucosylceramide (GlcCer) reprogramming on liver cancer metastasis remains poorly understood. In this study, we demonstrated that the protein expression of GBA1, which catalyses the conversion of GlcCer to ceramide, was downregulated in liver cancer tissue. A clinical relevanc...

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Bibliographic Details
Main Authors: Zhidong Qiu, Xuehong Wang, Zebin Yang, Sicong Liao, Wei Dong, Tian Sun, Huixian Wu, Qinqin Zhang, Zhixiong Pan, Sin Man Lam, Guanghou Shui, Junfei Jin
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04968-6

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https://doi.org/10.1038/s41419-022-04968-6

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