The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible
Abstract Background Transbronchial lung cryobiopsy (TBLB) is routinely used to diagnose the interstitial lung disease (ILD). These results are consistent with those of surgical lung biopsy. Fluoroscopy is also used to confirm the final position of the cryoprobe; however, it can increase radiation ex...
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Language: | English |
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Wiley
2023-10-01
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Series: | The Clinical Respiratory Journal |
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Online Access: | https://doi.org/10.1111/crj.13669 |
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author | Yu Zheng Liyan Zhang Yueyan Lou Bijun Fan Yongqi Cui Xueling Wu Xiaoming Tan |
author_facet | Yu Zheng Liyan Zhang Yueyan Lou Bijun Fan Yongqi Cui Xueling Wu Xiaoming Tan |
author_sort | Yu Zheng |
collection | DOAJ |
description | Abstract Background Transbronchial lung cryobiopsy (TBLB) is routinely used to diagnose the interstitial lung disease (ILD). These results are consistent with those of surgical lung biopsy. Fluoroscopy is also used to confirm the final position of the cryoprobe; however, it can increase radiation exposure for both patients and medical care personnel. Probe‐based confocal laser endomicroscopy (pCLE) is a novel optical imaging technique that allows real‐time imaging at the cellular level in vivo. pCLE technology can also be used to identify malignancy, acute rejection in lung transplantation, amiodarone lung, and pulmonary alveolar proteinosis and visualize elastin fibres in the alveolar compartment. Objectives The aim of this study is to investigate the ability of pCLE to distinguish fibrotic pulmonary issues from normal lung disease and the safety and feasibility of CLE‐guided bronchoscopy and transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD). Methods pCLE images from 17 ILD patients were obtained during TBLB. These images were then compared with histology results to assess the correspondence rate. Results pCLE imaging of the alveolar structures was performed. Key characteristics were visible, which could potentially influence the diagnostic rate (fibrotic areas) and the complication rate (blood vessel and pleura). Conclusion pCLE may reduce complications and increase the diagnostic yield. It is a potential guidance tool for cryobiopsy in the patients with ILD without fluoroscopy. |
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issn | 1752-6981 1752-699X |
language | English |
last_indexed | 2024-03-11T20:36:27Z |
publishDate | 2023-10-01 |
publisher | Wiley |
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series | The Clinical Respiratory Journal |
spelling | doaj.art-8ddc194706bd453e880ea4574f26cba82023-10-02T06:33:21ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-10-011710998100510.1111/crj.13669The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasibleYu Zheng0Liyan Zhang1Yueyan Lou2Bijun Fan3Yongqi Cui4Xueling Wu5Xiaoming Tan6Department of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Respiratory Medicine, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai ChinaAbstract Background Transbronchial lung cryobiopsy (TBLB) is routinely used to diagnose the interstitial lung disease (ILD). These results are consistent with those of surgical lung biopsy. Fluoroscopy is also used to confirm the final position of the cryoprobe; however, it can increase radiation exposure for both patients and medical care personnel. Probe‐based confocal laser endomicroscopy (pCLE) is a novel optical imaging technique that allows real‐time imaging at the cellular level in vivo. pCLE technology can also be used to identify malignancy, acute rejection in lung transplantation, amiodarone lung, and pulmonary alveolar proteinosis and visualize elastin fibres in the alveolar compartment. Objectives The aim of this study is to investigate the ability of pCLE to distinguish fibrotic pulmonary issues from normal lung disease and the safety and feasibility of CLE‐guided bronchoscopy and transbronchial lung cryobiopsy (TBLC) in patients with interstitial lung disease (ILD). Methods pCLE images from 17 ILD patients were obtained during TBLB. These images were then compared with histology results to assess the correspondence rate. Results pCLE imaging of the alveolar structures was performed. Key characteristics were visible, which could potentially influence the diagnostic rate (fibrotic areas) and the complication rate (blood vessel and pleura). Conclusion pCLE may reduce complications and increase the diagnostic yield. It is a potential guidance tool for cryobiopsy in the patients with ILD without fluoroscopy.https://doi.org/10.1111/crj.13669interstitial lung diseasesprobe‐based confocal laser endomicroscopyreal‐time imagingtransbrochial lung cryobiopsy |
spellingShingle | Yu Zheng Liyan Zhang Yueyan Lou Bijun Fan Yongqi Cui Xueling Wu Xiaoming Tan The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible The Clinical Respiratory Journal interstitial lung diseases probe‐based confocal laser endomicroscopy real‐time imaging transbrochial lung cryobiopsy |
title | The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible |
title_full | The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible |
title_fullStr | The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible |
title_full_unstemmed | The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible |
title_short | The cryobiopsy in interstitial lung diseases guided by probe‐based confocal laser endomicroscopy is feasible |
title_sort | cryobiopsy in interstitial lung diseases guided by probe based confocal laser endomicroscopy is feasible |
topic | interstitial lung diseases probe‐based confocal laser endomicroscopy real‐time imaging transbrochial lung cryobiopsy |
url | https://doi.org/10.1111/crj.13669 |
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