Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF

Pathologically Decreased CSF Levels of Synaptic Marker NPTX2 in DLB Are Correlated with Levels of Alpha-Synuclein and VGF

<b>Background:</b> Dementia with Lewy bodies (DLB) is a neurodegenerative disease where synaptic loss and reduced synaptic integrity are important neuropathological substrates. Neuronal Pentraxin 2(NPTX2) is a synaptic protein that drives the GABAergic inhibitory circuit. Our aim was to...

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Bibliographic Details
Main Authors: Walter A. Boiten, Inger van Steenoven, Mei-Fang Xiao, Paul F. Worley, Barbara Noli, Cristina Cocco, Gian-Luca Ferri, Afina W. Lemstra, Charlotte E. Teunissen
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
dementia with Lewy bodies
Alzheimer’s disease
neuronal pentraxin 2
VGF (non-acronym)
α-synuclein
biomarkers
Online Access:https://www.mdpi.com/2073-4409/10/1/38

Internet

https://www.mdpi.com/2073-4409/10/1/38

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