Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma

Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunogenomics pipeline to identify candidate neoantigens...

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Bibliographic Details
Main Authors: Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
Format: Article
Language:English
Published: Taylor & Francis Group 2019-04-01
Series:OncoImmunology
Subjects:
neoantigen
immunogenomics
glioblastoma
personalized vaccine
clonal evolution
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1561106

Internet

http://dx.doi.org/10.1080/2162402X.2018.1561106

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