Melatonin Synergizes With Methylprednisolone to Ameliorate Acute Spinal Cord Injury

Melatonin Synergizes With Methylprednisolone to Ameliorate Acute Spinal Cord Injury

Methylprednisolone (MP) is the drug of choice for treating spinal cord injury (SCI), but the aggressive dosage regimen used often results in adverse side effects. Therefore, MP should be combined with other drugs to lower the required dose. Melatonin is effective in alleviating nerve damage and inhi...

Full description

Bibliographic Details
Main Authors: Jiaqi Bi, Peiyu Sun, Erwei Feng, Jianxiong Shen, Chong Chen, Haining Tan, Zheng Li, Youxi Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
melatonin
methylprednisolone
spinal cord injury
factorial design
PI3K-AKT1 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.723913/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.723913/full

Similar Items