CCAAT/Enhancer-Binding Protein ε<sup>27</sup> Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding

CCAAT/Enhancer-Binding Protein ε<sup>27</sup> Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding

CCAAT/enhancer binding protein epsilon (C/EBPε) is required for eosinophil differentiation, lineage-specific gene transcription, and expression of C/EBPε<sup>32</sup> and shorter 27kD and 14kD isoforms is developmentally regulated during this process. We previously defined the 27kD isofo...

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Bibliographic Details
Main Authors: Monika J. Stankiewicz, Jian Du, Dominick Martinico, Steven J. Ackerman
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
eosinophil
granulocyte
transcription factor
repressor domain
sumoylation
terminal differentiation
Online Access:https://www.mdpi.com/1422-0067/22/23/12689

Internet

https://www.mdpi.com/1422-0067/22/23/12689

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