Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions
Levocetirizine dihydrochloride (LCTZ) is a second-generation antihistamine known for its efficacy without sedation. However, the binding mechanism with plasma protein which makes it devoid of sedative effects is yet to be uncovered. In this study, we elucidated thermodynamic parameters of solute-sol...
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Elsevier
2023-04-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023015700 |
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| author | Nur Farahani Zolkiflee Meor Mohd Redzuan Meor Mohd Affandi Abu Bakar Abdul Majeed |
| author_facet | Nur Farahani Zolkiflee Meor Mohd Redzuan Meor Mohd Affandi Abu Bakar Abdul Majeed |
| author_sort | Nur Farahani Zolkiflee |
| collection | DOAJ |
| description | Levocetirizine dihydrochloride (LCTZ) is a second-generation antihistamine known for its efficacy without sedation. However, the binding mechanism with plasma protein which makes it devoid of sedative effects is yet to be uncovered. In this study, we elucidated thermodynamic parameters of solute-solvent and solute-cosolute interactions between LCTZ, and the amino acids l-alanine (Ala) and l-glutamine (Gln) in aqueous solutions. The volumetric and conductance parameters were calculated using the experimental density and conductance data of aqueous solutions of Ala and Gln (concentration range of 0.02–0.20 mol kg−1) and LCTZ (concentration range of 0.01, 0.07, and 0.13 mol kg−1) at 298.15, 303.15, 308.15, and 313.15 K. Volumetric analysis study revealed that the apparent molar volume (Vφ), limiting apparent molar volume (Vφ0), and Masson's coefficient (Sv) values indicated predominantly solute-solvent interactions that were influenced by the solute's concentration and temperature. Meanwhile, partial molar expansibilities (Eφ0), transfer volume ΔtrVφ0 and Hepler's constant (δ2V0/δT2) established the solution system's structure-breaking tendency. The Gibb's free energy (ΔG0) values derived from conductometry data indicated the system's spontaneity. These calculated constants provided a detailed understanding of the different types of intermolecular interactions found in the ternary (LCTZ + water + amino acids) system. |
| first_indexed | 2024-04-09T15:19:27Z |
| format | Article |
| id | doaj.art-8de74762c7e24affba0d72272bc9e5cc |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:19:27Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
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| series | Heliyon |
| spelling | doaj.art-8de74762c7e24affba0d72272bc9e5cc2023-04-29T14:50:16ZengElsevierHeliyon2405-84402023-04-0194e14363Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutionsNur Farahani Zolkiflee0Meor Mohd Redzuan Meor Mohd Affandi1Abu Bakar Abdul Majeed2Laboratory Fundamental of Pharmaceutics, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, MalaysiaLaboratory Fundamental of Pharmaceutics, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Pharmaceutical and Life Sciences ReNeU, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, Malaysia; Corresponding author. Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia.Brain Research Laboratory, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, 42300, Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia; Pharmaceutical and Life Sciences ReNeU, Universiti Teknologi MARA (UiTM), 40450, Shah Alam, Selangor Darul Ehsan, MalaysiaLevocetirizine dihydrochloride (LCTZ) is a second-generation antihistamine known for its efficacy without sedation. However, the binding mechanism with plasma protein which makes it devoid of sedative effects is yet to be uncovered. In this study, we elucidated thermodynamic parameters of solute-solvent and solute-cosolute interactions between LCTZ, and the amino acids l-alanine (Ala) and l-glutamine (Gln) in aqueous solutions. The volumetric and conductance parameters were calculated using the experimental density and conductance data of aqueous solutions of Ala and Gln (concentration range of 0.02–0.20 mol kg−1) and LCTZ (concentration range of 0.01, 0.07, and 0.13 mol kg−1) at 298.15, 303.15, 308.15, and 313.15 K. Volumetric analysis study revealed that the apparent molar volume (Vφ), limiting apparent molar volume (Vφ0), and Masson's coefficient (Sv) values indicated predominantly solute-solvent interactions that were influenced by the solute's concentration and temperature. Meanwhile, partial molar expansibilities (Eφ0), transfer volume ΔtrVφ0 and Hepler's constant (δ2V0/δT2) established the solution system's structure-breaking tendency. The Gibb's free energy (ΔG0) values derived from conductometry data indicated the system's spontaneity. These calculated constants provided a detailed understanding of the different types of intermolecular interactions found in the ternary (LCTZ + water + amino acids) system.http://www.sciencedirect.com/science/article/pii/S2405844023015700Conductometric studyDrug-amino acid interactionsPhysicochemicalSolute-solute interactionsSolute-solvent interactionsThermodynamics |
| spellingShingle | Nur Farahani Zolkiflee Meor Mohd Redzuan Meor Mohd Affandi Abu Bakar Abdul Majeed Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions Heliyon Conductometric study Drug-amino acid interactions Physicochemical Solute-solute interactions Solute-solvent interactions Thermodynamics |
| title | Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions |
| title_full | Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions |
| title_fullStr | Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions |
| title_full_unstemmed | Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions |
| title_short | Volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l-alanine and l-glutamine in aqueous solutions |
| title_sort | volumetric and conductivity studies of the interaction between levocetirizine dihydrochloride and the amino acids l alanine and l glutamine in aqueous solutions |
| topic | Conductometric study Drug-amino acid interactions Physicochemical Solute-solute interactions Solute-solvent interactions Thermodynamics |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023015700 |
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