Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency

Pathogenic variants in the human m6A reader YTHDC2 are associated with primary ovarian insufficiency

Primary ovarian insufficiency (POI) affects 1% of women and carries significant medical and psychosocial sequelae. Approximately 10% of POI has a defined genetic cause, with most implicated genes relating to biological processes involved in early fetal ovary development and function. Recently, Ythdc...

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Bibliographic Details
Main Authors: Sinéad M. McGlacken-Byrne, Ignacio Del Valle, Polona Le Quesne Stabej, Laura Bellutti, Luz Garcia-Alonso, Louise A. Ocaka, Miho Ishida, Jenifer P. Suntharalingham, Andrey Gagunashvili, Olumide K. Ogunbiyi, Talisa Mistry, Federica Buonocore, GOSgene, Berta Crespo, Nadjeda Moreno, Paola Niola, Tony Brooks, Caroline E. Brain, Mehul T. Dattani, Daniel Kelberman, Roser Vento-Tormo, Carlos F. Lagos, Gabriel Livera, Gerard S. Conway, John C. Achermann
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-03-01
Series:JCI Insight
Subjects:
Endocrinology
Genetics
Online Access:https://doi.org/10.1172/jci.insight.154671

Internet

https://doi.org/10.1172/jci.insight.154671

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