Escalated Oxycodone Self-Administration and Punishment: Differential Expression of Opioid Receptors and Immediate Early Genes in the Rat Dorsal Striatum and Prefrontal Cortex

Escalated Oxycodone Self-Administration and Punishment: Differential Expression of Opioid Receptors and Immediate Early Genes in the Rat Dorsal Striatum and Prefrontal Cortex

Opioid use disorder (OUD) is characterized by compulsive drug taking despite adverse life consequences. Here, we sought to identify neurobiological consequences associated with the behavioral effects of contingent footshocks administered after escalation of oxycodone self-administration. To reach th...

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Bibliographic Details
Main Authors: Christopher A. Blackwood, Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Neuroscience
Subjects:
oxycodone
opioid receptors
protein
mRNA
footshocks
prefrontal cortex
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01392/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.01392/full

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