Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment

Development and validation of an advanced ex vivo brain slice invasion assay to model glioblastoma cell invasion into the complex brain microenvironment

Organotypic cultures of murine brain slices are well-established tools in neuroscience research, including electrophysiology studies, modeling neurodegeneration, and cancer research. Here, we present an optimized ex vivo brain slice invasion assay that models glioblastoma multiforme (GBM) cell invas...

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Bibliographic Details
Main Authors: Lisa R. Decotret, Rocky Shi, Kiersten N. Thomas, Manchi Hsu, Catherine J. Pallen, Kevin L. Bennewith
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
organotypic brain slice culture
brain microenvironment
invasion
metastasis
glioblastoma multiforme
confocal microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.976945/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.976945/full

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